Parallel chemoenzymatic synthesis of sialosides containing a C5-diversified sialic acid.

ABSTRACT: A convenient chemoenzymatic strategy for synthesizing sialosides containing a C5-diversified sialic acid was developed. The alpha2,3- and alpha2,6-linked sialosides containing a 5-azido neuraminic acid synthesized by a highly efficient one-pot three-enzyme approach were converted to C5''-amino sialosides, which were used as common intermediates for chemical parallel synthesis to quickly generate a series of sialosides containing various sialic acid forms.

SUBMITTER: Cao H 

PROVIDER: S-EPMC2753693 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature