Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.

ABSTRACT:

Rationale

Increased production of mucus is a prominent feature of asthma. IL-13-driven mucous cell metaplasia is associated with decreased expression of the transcription factor FOXA2 and increased expression of the related transcription factor FOXA3 in animal and cell culture models.

Objectives

Establish how changes in FOXA2 and FOXA3 expression contribute to mucous metaplasia and determine whether FOXA2 and FOXA3 expression is altered in asthma.

Methods

Mice expressing a Foxa2 transgene in airway epithelial cells and mice deficient in Foxa3 were analyzed after allergen sensitization and challenge. Expression of FOXA2, FOXA3, MUC5AC, and the highly IL-13-inducible gene CLCA1 was analyzed in airway biopsies from subjects with asthma and control subjects.

Measuremen

SUBMITTER: Park SW 

PROVIDER: S-EPMC2753788 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature