Role of insulin-like growth factor binding protein-3 in allergic airway remodeling.

ABSTRACT:

Rationale

The hallmarks of allergic asthma are airway inflammation, obstruction, and remodeling. Airway remodeling may lead to irreversible airflow obstruction with increased morbidity and mortality. Despite advances in the treatment of asthma, the mechanisms underlying airway remodeling are still poorly understood. We reported that insulin-like growth factor (IGF) binding proteins (IGFBPs) contribute to extracellular matrix deposition in idiopathic pulmonary fibrosis; however, their contribution to airway remodeling in asthma has not been established.

Objectives

We hypothesized that IGFBP-3 is overexpressed in asthma and contributes to airway remodeling.

Methods

We evaluated levels of IGFBP-3 in tissues and bronchoalveolar lavage fluid from patients with asthma at ba

SUBMITTER: Veraldi KL 

PROVIDER: S-EPMC2753789 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature