Kidney function is associated with the rate of cognitive decline in the elderly.

ABSTRACT:

Objective

We tested the hypothesis that impaired kidney function in the elderly is associated with a more rapid rate of cognitive decline.

Methods

Baseline serum was used to calculate estimated glomerular filtration rate (eGFR), using the Modification of Diet in Renal Disease formula, for 886 elderly without dementia participating in the Rush Memory and Aging Project, a prospective, observational cohort study. Kidney function was also dichotomized into impairment or no impairment based on eGFR < or >or=60 mL/min/1.73 m(2). Structured cognitive testing was performed at baseline and at annual evaluations, using a battery of 19 cognitive tests summarized into global cognition and 5 cognitive domains.

Results

In mixed-effects models adjusted for age, sex, and education, a

SUBMITTER: Buchman AS 

PROVIDER: S-EPMC2754333 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature