Association study of AMP-activated protein kinase subunit genes in polycystic ovary syndrome.

ABSTRACT:

Objective

To examine the genes for AMP-activated protein kinase (AMPK) subunits alpha2 (PRKAA2) and gamma3 (PRKAG3) as candidates for polycystic ovary syndrome (PCOS) and its component traits.

Design and methods

A total of 287 white PCOS women were recruited from the reproductive endocrinology clinic at the University of Alabama at Birmingham and 187 white control subjects were recruited from the surrounding community. Seven PRKAA2 single nucleotide polymorphisms (SNPs) and four PRKAG3 SNPs were genotyped in PCOS cases and controls. Genotyping and association analysis were performed at Cedars-Sinai Medical Center.

Results

Nominal associations of PRKAA2 variants with insulin-related traits and the PRKAG3 Pro71Ala variant with PCOS were not statistically significant aft

SUBMITTER: Sproul K 

PROVIDER: S-EPMC2754574 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature