Molecular signatures reveal circadian clocks may orchestrate the homeorhetic response to lactation.

ABSTRACT: Genes associated with lactation evolved more slowly than other genes in the mammalian genome. Higher conservation of milk and mammary genes suggest that species variation in milk composition is due in part to the environment and that we must look deeper into the genome for regulation of lactation. At the onset of lactation, metabolic changes are coordinated among multiple tissues through the endocrine system to accommodate the increased demand for nutrients and energy while allowing the animal to remain in homeostasis. This process is known as homeorhesis. Homeorhetic adaptation to lactation has been extensively described; however how these adaptations are orchestrated among multiple tissues remains elusive. To develop a clearer picture of how gene expression is coordinated across multiple

SUBMITTER: Casey T 

PROVIDER: S-EPMC2754660 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature