Gene positional changes relative to the nuclear substructure correlate with the proliferating status of hepatocytes during liver regeneration.

ABSTRACT: In the interphase nucleus the DNA of higher eukaryotes is organised in loops anchored to a proteinaceous substructure variously named but commonly known as the nuclear matrix. Important processes of nuclear physiology, such as replication, transcription and processing of primary transcripts, occur at macromolecular complexes located at discrete sites upon the nuclear substructure. The topological relationships between gene sequences located in the DNA loops and the nuclear substructure appear to be non-random, thus posing the question of whether such relationships remain invariant or change after the critical nuclear transitions associated with cell proliferation and tissue regeneration in vivo. The hepatocytes are cells that preserve a proliferating capacity that is readily displayed afte

SUBMITTER: Maya-Mendoza A 

PROVIDER: S-EPMC275467 | biostudies-literature | 2003 Nov

REPOSITORIES: biostudies-literature