Association of scavenger receptors in adipose tissue with insulin resistance in nondiabetic humans.

ABSTRACT:

Objective

Scavenger receptors play crucial roles in the pathogenesis of atherosclerosis, but their role in insulin resistance has not been explored. We hypothesized that scavenger receptors are present in human adipose tissue resident macrophages, and their gene expression is regulated by adiponectin and thaizolidinediones.

Methods and results

The gene expression of scavenger receptors including scavenger receptor-A (SRA), CD36, and lectin-like oxidized LDL receptor-1 (LOX-1) were studied in subcutaneous adipose tissue of nondiabetic subjects and in vitro. Adipose tissue SRA expression was independently associated with insulin resistance. Pioglitazone downregulated SRA gene expression in adipose tissue of subjects with impaired glucose tolerance and decreased LOX-1 mRNA in v

SUBMITTER: Rasouli N 

PROVIDER: S-EPMC2755066 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature