Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1.

ABSTRACT:

Aim

Several studies have indicated that genes in the human leucocyte antigen (HLA) region additional to the HLA class II DRB1-DQB1 contribute to type 1 diabetes (T1D) susceptibility. The aim of this study was to assess if markers in the class III Major Histocompatibility Complex (MHC) region are associated with T1D after accounting for linkage disequilibrium (LD) with DRB1-DQB1.

Methods

We investigated 356 single nucleotide polymorphisms (SNPs) in the class III region covering 1.1 megabases in two subsets of data: 289 Human Biological Data Interchange (HBDI) Caucasian families and 597 additional Caucasian families collected by the Type 1 Diabetes Genetics Consortium (T1DGC). Analysis conditioning on DRB1-DQB1 was performed using the overall conditional genotype method.

Re

SUBMITTER: Valdes AM 

PROVIDER: S-EPMC2755069 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature