Return of chronic pelvic pain from endometriosis after raloxifene treatment: a randomized controlled trial.

ABSTRACT:

Objective

To evaluate whether 6 months of raloxifene was effective in treatment of chronic pelvic pain in women with endometriosis.

Methods

Women with chronic pelvic pain and no endometriosis treatment for 6 months underwent laparoscopy for excision of all lesions. Those with biopsy-proven endometriosis were randomly allocated to raloxifene (180 mg) or placebo daily. A second laparoscopy was performed at 2 years, or earlier, if pain returned. Return of pain was defined as 2 months of pain equal to or more severe than that at study entry. Menstrual cycles and adverse events were recorded. The log rank test was used to compare the time to return of pain by drug group. Analyses were done as intent-to-treat.

Results

A total of 127 of 158 women underwent surgery. Of these,

SUBMITTER: Stratton P 

PROVIDER: S-EPMC2755201 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature