Selection of HIV variants with signature genotypic characteristics during heterosexual transmission.

ABSTRACT:

Background

Newly infected subjects acquire a limited number of human immunodeficiency virus type 1 (HIV-1) variants with specific genotypic and phenotypic features from the array of viruses present in a chronically infected transmitting partner.

Methods

We examined HIV-1 envelope sequences from the earliest available serum sample after HIV-1 acquisition in 13 newly infected subjects and from their epidemiologically linked HIV-1-infected heterosexual partner. Samples from both members were collected on the same day in the Rakai Community Cohort Study.

Results

Ten couples were infected with subtype D HIV-1, and 3 pairs had subtype A HIV-1. Newly infected subjects acquired a subset of the viruses that were circulating in the transmitting partner; transmitted variants had

SUBMITTER: Sagar M 

PROVIDER: S-EPMC2755256 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature