Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis.

ABSTRACT:

Background

We evaluated the magnitude of the reported associations between amygdala activation and the serotonin transporter gene linked polymorphic region (5-HTTLPR) and the likely effect size of this relationship.

Methods

We used meta-analytic techniques to combine data from existing published and unpublished studies. We also tested for possible publication bias and explored possible moderating influences on any association, such as sample ancestry.

Results

Our results provide support for the association of the 5-HTTLPR polymorphism and amygdala activation and suggest that this locus may account for up to 10% of phenotypic variance. Although we did not observe evidence for potential publication bias in our main analysis, this was due in part to efforts to obtain unp

SUBMITTER: Munafo MR 

PROVIDER: S-EPMC2755289 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature