Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach.

ABSTRACT:

Aim

The Major Histocompatibility Complex (MHC) is a highly polymorphic region on chromosome 6 encompassing the human leucocyte antigen (HLA)-DQ/DR loci most predictive of susceptibility to type 1 diabetes (T1D). To assess the contribution of other MHC genes, in this exploratory analysis of Type 1 Diabetes Genetics Consortium (T1DGC) family data we characterize association between susceptibility and MHC single nucleotide polymorphism (SNP) genotype, with an emphasis on effects of genetic variation additional to carriage of predisposing or protective MHC haplotypes.

Methods

We use Cox regression analyses of age of onset, stratified by family, to jointly test both linkage and association. Analysis is restricted to children from families having both affected and unaffected sibli

SUBMITTER: McKinnon E 

PROVIDER: S-EPMC2755510 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature