Common sequence variants on 20q11.22 confer melanoma susceptibility.

ABSTRACT: We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.

SUBMITTER: Brown KM 

PROVIDER: S-EPMC2755512 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature