Genes that may modulate longevity in C. elegans in both dauer larvae and long-lived daf-2 adults.

ABSTRACT: We used Serial Analysis of Gene Expression (SAGE) to compare the global transcription profiles of long-lived mutant daf-2 adults and dauer larvae, aiming to identify aging-related genes based on similarity of expression patterns. Genes that are expressed similarly in both long-lived types potentially define a common life-extending program. Comparison of eight SAGE libraries yielded a set of 120 genes, the expression of which was significantly different in long-lived worms vs. normal adults. The gene annotations indicate a strong link between oxidative stress and life span, further supporting the hypothesis that metabolic activity is a major determinant in longevity. The SAGE data show changes in mRNA levels for electron transport chain components, elevated expression of glyoxylate shunt en

SUBMITTER: Ruzanov P 

PROVIDER: S-EPMC2755518 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature