Ontology highlight
ABSTRACT:
SUBMITTER: Sparman M
PROVIDER: S-EPMC2755529 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Stem cells (Dayton, Ohio) 20090601 6
We recently demonstrated that somatic cells from adult primates could be reprogrammed into a pluripotent state by somatic cell nuclear transfer. However, the low efficiency with donor cells from one monkey necessitated the need for large oocyte numbers. Here, we demonstrate nearly threefold higher blastocyst development and embryonic stem (ES) cell derivation rates with different nuclear donor cells. Two ES cell lines were isolated using adult female rhesus macaque skin fibroblasts as nuclear do ...[more]