AXIN2 and CDH1 polymorphisms, tooth agenesis, and oral clefts.

ABSTRACT:

Background

AXIN2 and CDH1 genes play important roles during craniofacial morphogenesis. Mutations in these genes have been described in families presenting colorectal cancer and tooth agenesis, and gastric cancer and cleft lip/palate (CL/P). Oral clefts have been associated with tooth agenesis. We investigated if AXIN2 and CDH1 polymorphisms were associated with clefts or with any associated dental subphenotypes.

Methods

Markers in AXIN2 and CDH1 were genotyped using Taqman chemistry in a sample cohort comprised of 500 cleft individuals and 500 unrelated controls.

Results

Comparison between cleft and control groups showed a trend for association for AXIN2 with incomplete cleft palate (p = .006) and CDH1 with unilateral CL/P (p = .03 for left CL/P and p = .04 for right

SUBMITTER: Letra A 

PROVIDER: S-EPMC2755581 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature