Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening.

ABSTRACT:

Background

A number of adhesion-mediated signaling pathways and cell-cycle events have been identified that regulate cell proliferation, yet studies to date have been unable to determine which of these pathways control mitogenesis in response to physiologically relevant changes in tissue elasticity. In this report, we use hydrogel-based substrata matched to biological tissue stiffness to investigate the effects of matrix elasticity on the cell cycle.

Results

We find that physiological tissue stiffness acts as a cell-cycle inhibitor in mammary epithelial cells and vascular smooth muscle cells; subcellular analysis in these cells, mouse embryonic fibroblasts, and osteoblasts shows that cell-cycle control by matrix stiffness is widely conserved. Remarkably, most mitogenic event

SUBMITTER: Klein EA 

PROVIDER: S-EPMC2755619 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature