Determination of optimal rhodamine fluorophore for in vivo optical imaging.

ABSTRACT: Optical imaging has the potential to improve the efficacy of surgical and endoscopic approaches to cancer treatment; however, the optimal type of fluorescent probe has not yet been established. It is well-known that rhodamine-core-derived fluorophores offer a combination of desirable properties such as good photostability, high extinction coefficient, and high fluorescence quantum yield. However, despite the ubiquitous use of rhodamine fluorophores for in vivo optical imaging, it remains to be determined if unique chemical properties among individual rhodamine core family members affect fluorophore parameters critical to in vivo optical imaging applications. These parameters include preserved fluorescence intensity in low pH environments, similar to that of the endolysosome; efficient fluo

SUBMITTER: Longmire MR 

PROVIDER: S-EPMC2756081 | biostudies-literature | 2008 Aug

REPOSITORIES: biostudies-literature