Self-assembly and lipid interactions of diacylglycerol lactone derivatives studied at the air/water interface.

ABSTRACT: Synthetic diacylglycerol lactones (DAG-lactones) have been shown to be effective modulators of critical cellular signaling pathways. The biological activity of these amphiphilic molecules depends in part upon their lipid interactions within the cellular plasma membrane. This study explores the thermodynamic and structural features of DAG-lactone derivatives and their lipid interactions at the air/water interface. Surface-pressure/area isotherms and Brewster angle microscopy revealed the significance of specific side-groups attached to the terminus of a very rigid 4-(2-phenylethynyl)benzoyl chain of the DAG-lactones, which affected both the self-assembly of the molecules and their interactions with phospholipids. The experimental data highlight the formation of different phases within mixed

SUBMITTER: Philosof-Mazor L 

PROVIDER: S-EPMC2756192 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature