The effect of branch lengths on phylogeny: an empirical study using highly conserved orthologs from mammalian genomes.

ABSTRACT: Phylogenetic analyses were applied to 269 families of putative orthologs represented by a single member in the genomes of human, mouse, dog, and chicken. Five methods were used: maximum parsimony (NP), neighbor-joining (NJ) with Poisson and Gamma distances; and maximum likelihood (ML) with JTT and JTT+gamma models. When applied to the concatenated sequence of all families, all methods strongly supported a tree in which mouse branched before human and dog. In analyses of individual families, the same topology was supported more than any other. Although there was evidence of an increased rate of amino acid replacement in the mouse lineage in comparison to the other two mammals, there was no evidence that support for the mouse's basal position was due to long-branch attraction; rather, this t

SUBMITTER: Hughes AL 

PROVIDER: S-EPMC2756227 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature