Differential regulation of action potentials by inactivating and noninactivating BK channels in rat adrenal chromaffin cells.

ABSTRACT: Large-conductance Ca(2+)-activated K(+) (BK) channels can regulate cellular excitability in complex ways because they are able to respond independently to two distinct cellular signals, cytosolic Ca(2+) and membrane potential. In rat chromaffin cells (RCC), inactivating BK(i) and noninactivating (BK(s)) channels differentially contribute to RCC action potential (AP) firing behavior. However, the basis for these differential effects has not been fully established. Here, we have simulated RCC action potential behavior, using Markovian models of BK(i) and BK(s) current and other RCC currents. The analysis shows that BK current influences both fast hyperpolarization and afterhyperpolarization of single APs and that, consistent with experimental observations, BK(i) current facilitates repetitiv

SUBMITTER: Sun L 

PROVIDER: S-EPMC2756402 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature