Benchmark experimental data set and assessment of adsorption free energy for peptide-surface interactions.

ABSTRACT: With the increasing interest in protein adsorption in fields ranging from bionanotechnology to biomedical engineering, there is a growing need to understand protein-surface interactions at a fundamental level, such as the interaction between individual amino acid residues of a protein and functional groups presented by a surface. However, relatively little data are available that experimentally provide a quantitative, comparative measure of these types of interactions. To address this deficiency, the objective of this study was to generate a database of experimentally measured standard state adsorption free energy (DeltaGoads) values for a wide variety of amino acid residue-surface interactions using a host-guest peptide and alkanethiol self-assembled monolayers (SAMs) with polymer-like fu

SUBMITTER: Wei Y 

PROVIDER: S-EPMC2756418 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature