Loss of heterozygosity at 2q37 in sporadic Wilms' tumor: putative role for miR-562.

ABSTRACT:

Purpose

Wilms' tumor is a childhood cancer of the kidney with an incidence of approximately 1 in 10,000. Cooccurrence of Wilms' tumor with 2q37 deletion syndrome, an uncommon constitutional chromosome abnormality, has been reported previously in three children. Given these are independently rare clinical entities, we hypothesized that 2q37 harbors a tumor suppressor gene important in Wilms' tumor pathogenesis.

Experimental design

To test this, we performed loss of heterozygosity analysis in a panel of 226 sporadic Wilms' tumor samples and mutation analysis of candidate genes.

Results

Loss of heterozygosity was present in at least 4% of cases. Two tumors harbored homozygous deletions at 2q37.1, supporting the presence of a tumor suppressor gene that follows a classic t

SUBMITTER: Drake KM 

PROVIDER: S-EPMC2756455 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature