Association of the -243 A-->G polymorphism of the glutamate decarboxylase 2 gene with obesity in girls with premature pubarche.

ABSTRACT:

Objective

To test the a priori hypothesis that the frequency of a single-nucleotide polymorphism (SNP) located in the promoter region of the glutamate decarboxylase 2 (GAD2) gene (-243A-->G) would be overrepresented among children with higher body mass index (BMI) values.

Design

Genotype-phenotype correlation study.

Setting

University-based pediatric endocrinology practice.

Patient(s)

Eighty-seven girls with PP and 70 adolescent girls with hyperandrogenism.

Intervention(s)

Blood was obtained for genotype analysis, glucose measurement, and hormone (Delta(4)-A, insulin, 17-hydroxyprogesterone, and T) determinations.

Main outcome measure(s)

Frequency of this SNP in the GAD2 gene and correlation of this SNP with BMI and hormone concentrations.

Resu

SUBMITTER: Witchel SF 

PROVIDER: S-EPMC2756597 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature