MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis.

ABSTRACT:

Background

The physiopathology of sepsis continues to be poorly understood, and despite recent advances in its management, sepsis is still a life-threatening condition with a poor outcome. If new diagnostic markers related to sepsis pathogenesis will be identified, new specific therapies might be developed and mortality reduced. Small regulatory non-coding RNAs, microRNAs (miRNAs), were recently linked to various diseases; the aim of our prospective study was to identify miRNAs that can differentiate patients with early-stage sepsis from healthy controls and to determine if miRNA levels correlate with the severity assessed by the Sequential Organ Failure Assessment (SOFA) score.

Methodology/principal findings

By using genome-wide miRNA profiling by microarray in peripheral b

SUBMITTER: Vasilescu C 

PROVIDER: S-EPMC2756627 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature