Protein O-mannosyltransferases B and C support hyphal development and differentiation in Aspergillus nidulans.

ABSTRACT: Aspergillus nidulans possesses three pmt genes encoding protein O-d-mannosyltransferases (Pmt). Previously, we reported that PmtA, a member of the PMT2 subfamily, is involved in the proper maintenance of fungal morphology and formation of conidia (T. Oka, T. Hamaguchi, Y. Sameshima, M. Goto, and K. Furukawa, Microbiology 150:1973-1982, 2004). In the present paper, we describe the characterization of the pmtA paralogues pmtB and pmtC. PmtB and PmtC were classified as members of the PMT1 and PMT4 subfamilies, respectively. A pmtB disruptant showed wild-type (wt) colony formation at 30 degrees C but slightly repressed growth at 42 degrees C. Conidiation of the pmtB disruptant was reduced to approximately 50% of that of the wt strain; in addition, hyperbranching of hyphae indicated that PmtB i

SUBMITTER: Goto M 

PROVIDER: S-EPMC2756868 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature