Hypothesis for heritable, anti-viral immunity in crustaceans and insects.

ABSTRACT:

Background

It is known that crustaceans and insects can persistently carry one or more viral pathogens at low levels, without signs of disease. They may transmit them to their offspring or to naïve individuals, often with lethal consequences. The underlying molecular mechanisms have not been elucidated, but the process has been called viral accommodation. Since tolerance to one virus does not confer tolerance to another, tolerance is pathogen-specific, so the requirement for a specific pathogen response mechanism (memory) was included in the original viral accommodation concept. Later, it was hypothesized that specific responses were based on the presence of viruses in persistent infections. However, recent developments suggest that specific responses may be based on viral sequence

SUBMITTER: Flegel TW 

PROVIDER: S-EPMC2757015 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature