Integrative modeling of transcriptional regulation in response to antirheumatic therapy.

ABSTRACT:

Background

The investigation of gene regulatory networks is an important issue in molecular systems biology and significant progress has been made by combining different types of biological data. The purpose of this study was to characterize the transcriptional program induced by etanercept therapy in patients with rheumatoid arthritis (RA). Etanercept is known to reduce disease symptoms and progression in RA, but the underlying molecular mechanisms have not been fully elucidated.

Results

Using a DNA microarray dataset providing genome-wide expression profiles of 19 RA patients within the first week of therapy we identified significant transcriptional changes in 83 genes. Most of these genes are known to control the human body's immune response. A novel algorithm called TILA

SUBMITTER: Hecker M 

PROVIDER: S-EPMC2757030 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature