Sequence variants in host cell factor C1 are associated with Meniere's disease.

ABSTRACT:

Hypothesis

There is a genetic basis for the development of Ménière's (MD) disease.

Background

The cause of MD is unknown, although many potential theories have been proposed. A genetic basis for the disease is suggested by greater prevalence in Caucasians and familial cases that display an autosomal dominant pattern of inheritance.

Methods/design

Case-control association study of selected candidate genes among patients with MD and selected control individuals.

Results

Several single-nucleotide polymorphisms (SNPs) within the host cell factor C1 (HCFCI) gene displayed a significant increase in prevalence of the major allele in subjects with MD disease. The most individually significant SNP is rs2266886. The minor allele at this site displays an odds ratio of 0.2

SUBMITTER: Vrabec JT 

PROVIDER: S-EPMC2757044 | biostudies-literature | 2008 Jun

REPOSITORIES: biostudies-literature