Backward genotype-trait association (BGTA)-based dissection of complex traits in case-control designs.

ABSTRACT:

Background

The studies of complex traits project new challenges to current methods that evaluate association between genotypes and a specific trait. Consideration of possible interactions among loci leads to overwhelming dimensions that cannot be handled using current statistical methods.

Methods

In this article, we evaluate a multi-marker screening algorithm--the backward genotype-trait association (BGTA) algorithm for case-control designs, which uses unphased multi-locus genotypes. BGTA carries out a global investigation on a candidate marker set and automatically screens out markers carrying diminutive amounts of information regarding the trait in question. To address the 'too many possible genotypes, too few informative chromosomes' dilemma of a genomic-scale study that

SUBMITTER: Zheng T 

PROVIDER: S-EPMC2757084 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature