Genetic variation in angiotensin-converting enzyme-related pathways associated with sudden cardiac arrest risk.

ABSTRACT:

Background

Angiotensin-converting enzyme (ACE)-related pathways influence arrhythmias and sudden cardiac arrest (SCA) risk.

Objective

The purpose of this study was to investigate whether genetic variations in ACE-related pathways are associated with SCA risk. Because these pathways are sex dependent and are influenced by estrogen, we examined these genotype-SCA associations in the full study population and tested for interaction with gender.

Methods

In a population-based case-control study set in King County, Washington, 211 SCA cases (80% male; mean age 59 years,) and 730 age- and gender-matched controls of European descent were genotyped for 47 single nucleotide polymorphisms (SNPs) in eight genes (ACE, AGT, REN, AGTR1, AGTR2, ACE2, KNG1, BDKRB2). The association of

SUBMITTER: Sotoodehnia N 

PROVIDER: S-EPMC2757102 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature