HbA1c measured in stored erythrocytes and mortality rate among middle-aged and older women.

ABSTRACT:

Aims/hypothesis

Diabetes is known to increase mortality rate, but the degree to which mild hyperglycaemia may be associated with the risk of death is uncertain. We examined the association between HbA1c measured in stored erythrocytes and mortality rate in women with and without diabetes.

Methods

We conducted a cohort study of 27,210 women>or=45 years old with no history of cardiovascular disease or cancer who participated in the Women's Health Study, a randomised trial of vitamin E and aspirin.

Results

Over a median of 10 years of follow-up, 706 women died. Proportional hazards models adjusted for age, smoking, hypertension, blood lipids, exercise, postmenopausal hormone use, multivitamin use and C-reactive protein were used to estimate the relative risk of mortality

SUBMITTER: Levitan EB 

PROVIDER: S-EPMC2757266 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature