Histotripsy of the prostate: dose effects in a chronic canine model.

ABSTRACT:

Objectives

To develop the technique of histotripsy ultrasound therapy as a noninvasive treatment for benign prostatic hyperplasia and to examine the histotripsy dose-tissue response effect over time to provide an insight for treatment optimization. We have previously demonstrated the feasibility of prostate histotripsy fractionation in a canine model.

Methods

Various doses of histotripsy were applied transabdominally to the prostates of 20 canine subjects. Treated prostates were then harvested at interval time points from 0 to 28 days and assessed for histologic treatment response.

Results

The lowest dose applied was found to produce only scattered cellular disruption and necrosis, whereas higher doses produced more significant regions of tissue effect that resulted i

SUBMITTER: Hall TL 

PROVIDER: S-EPMC2757508 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature