Role of genetic susceptibility to latent adenoviral infection and decreased lung function.

ABSTRACT:

Background

Latent adenoviral infection may amplify cigarette smoke-induced lung inflammation and therefore play an important role in the development of chronic obstructive pulmonary disease (COPD). Adenoviruses can evade the human immune response via their 19-kDa protein (19K) which delays the expression of class I human leukocyte antigen (HLA) proteins. The 19K protein shows higher affinity to HLA-B7 and A2 compared with HLA-A1 and A3. The receptor for adenovirus (CXADR) and integrin beta(5) (ITGB5) are host factors which might affect adenovirus infection. Therefore, we investigated the contribution of HLA, CXADR, and ITGB5 genetic variants to the presence of the E1A gene and to level of lung function.

Methods

Study subjects were assayed for HLA-B7, A1, A2 and A3 by PCR-bas

SUBMITTER: Kasuga I 

PROVIDER: S-EPMC2757510 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature