A catalogue of Triticum monococcum genes encoding toxic and immunogenic peptides for celiac disease patients.

ABSTRACT: The celiac disease (CD) is an inflammatory condition characterized by injury to the lining of the small-intestine on exposure to the gluten of wheat, barley and rye. The involvement of gluten in the CD syndrome has been studied in detail in bread wheat, where a set of "toxic" and "immunogenic" peptides has been defined. For wheat diploid species, information on CD epitopes is poor. In the present paper, we have adopted a genomic approach in order to understand the potential CD danger represented by storage proteins in diploid wheat and sequenced a sufficiently large number of cDNA clones related to storage protein genes of Triticum monococcum. Four bona fide toxic peptides and 13 immunogenic peptides were found. All the classes of storage proteins were shown to contain harmful sequences. T

SUBMITTER: Vaccino P 

PROVIDER: S-EPMC2757618 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature