Variation of Neisseria gonorrhoeae lipooligosaccharide directs dendritic cell-induced T helper responses.

ABSTRACT: Gonorrhea is one of the most prevalent sexually transmitted diseases in the world. A naturally occurring variation of the terminal carbohydrates on the lipooligosaccharide (LOS) molecule correlates with altered disease states. Here, we investigated the interaction of different stable gonoccocal LOS phenotypes with human dendritic cells and demonstrate that each variant targets a different set of receptors on the dendritic cell, including the C-type lectins MGL and DC-SIGN. Neisseria gonorrhoeae LOS phenotype C constitutes the first bacterial ligand to be described for the human C-type lectin receptor MGL. Both MGL and DC-SIGN are locally expressed at the male and female genital area, the primary site of N. gonorrhoeae infection. We show that targeting of different C-type lectins with the N

SUBMITTER: van Vliet SJ 

PROVIDER: S-EPMC2757725 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature