Gene set enrichment analyses revealed differences in gene expression patterns between males and females.

ABSTRACT: Men and women differ not only in their physical attributes and reproductive functions but also in many other characteristics, including the risks for some diseases as well as response to certain therapeutic treatments. Though genetically-identical for autosomal chromosomes, males and females could have gender-specific transcriptional or translational regulation, leading to differential mRNAs or protein products for some genes. To illustrate the gender-specific differences in mRNA-level expression, we compared gene expression patterns between males and females using a whole-genome microarray dataset on the unrelated HapMap lymphoblastoid cell lines derived from individuals of European (58 individuals) and African (59 individuals) ancestry. We applied the Gene Set Enrichment Analysis to iden

SUBMITTER: Zhang W 

PROVIDER: S-EPMC2757739 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature