The role of transient outward K+ current in electrical remodelling induced by voluntary exercise in female rat hearts.

ABSTRACT: Regular exercise can lead to electrical remodelling of the heart. The cellular mechanisms associated with these changes are not well understood, and are difficult to study in human tissue but are important given that exercise is recommended to the general population. We have investigated the role played by the transient outward K+ current (I(to)) in the changes in electrical activity seen in response to voluntary exercise training in rats. Female rats undertook 6 weeks of voluntary wheel running exercise (TRN) or were sedentary controls (SED). Monophasic action potentials (MAPs) were recorded from the surface of whole hearts. Whole cell patch clamp recordings of I(to); mRNA and protein levels of selected targets in sub-epicardial (EPI) and sub-endocardial myocardium of SED and TRN hearts w

SUBMITTER: Stones R 

PROVIDER: S-EPMC2758204 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature