Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder: an MRI investigation.

ABSTRACT:

Purpose

determine if language disorder in children with autistic disorder (AD) corresponds to abnormalities in hemispheric asymmetries in auditory language cortex.

Methods

MRI morphometric study in children with AD (n = 50) to assess hemispheric asymmetries in auditory language cortex. A key region of interest was the planum temporale (PT), which is larger in the left hemisphere in most healthy individuals.

Results

(i) Heschl's gyrus and planum polare showed typical hemisphere asymmetry patterns; (ii) posterior Superior Temporal Gyrus (pSTG) showed significant rightward asymmetry; and (iii) PT showed a trend for rightward asymmetry that was significant when constrained to right-handed boys (n = 30). For right-handed boys, symmetry indices for pSTG were significantly p

SUBMITTER: Gage NM 

PROVIDER: S-EPMC2758220 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature