Protective effects of NSAIDs on the development of Alzheimer disease.

ABSTRACT:

Background

Nonsteroidal anti-inflammatory drugs (NSAIDs) may protect against Alzheimer disease (AD), but observational studies and trials have offered contradictory results. Prior studies have also been relatively short and small. We examined the effects on AD risk of NSAID use for >5 years and of NSAIDs that suppress formation of A beta (1-42) amyloid in a large health care database.

Methods

Cases were veterans aged 55 years and older with incident AD using the US Veterans Affairs Health Care system. Matched controls were drawn from the same population. NSAID exposure was categorized into seven time periods: no use, 1 but

SUBMITTER: Vlad SC 

PROVIDER: S-EPMC2758242 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature