Long-term outcome of biopsy-proven, frequently relapsing minimal-change nephrotic syndrome in children.

ABSTRACT:

Background and objectives

Frequently relapsing and steroid-dependent minimal-change nephrotic syndrome (MCNS) that originates in childhood can persist after puberty in >20% of patients. These patients require immunosuppressive treatment during several decades of their life. We examined long-term adverse effects of persistent nephrotic syndrome and immunosuppressive medications, focusing on renal function, growth, obesity, osteoporosis, hypertension, ocular complications, and fertility in adult patients with biopsy-proven childhood-onset MCNS. Molecular analysis was performed to evaluate a possible association of a complicated course of MCNS with podocyte gene mutations.

Design, setting, participants, & measurements

We performed a prospective clinical examination of 15 adult

SUBMITTER: Kyrieleis HA 

PROVIDER: S-EPMC2758253 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature