Microbleeds versus macrobleeds: evidence for distinct entities.

ABSTRACT:

Background and purpose

Small, asymptomatic microbleeds commonly accompany larger symptomatic macrobleeds. It is unclear whether microbleeds and macrobleeds represent arbitrary categories within a single continuum versus truly distinct events with separate pathophysiologies.

Methods

We performed 2 complementary retrospective analyses. In a radiographic analysis, we measured and plotted the volumes of all hemorrhagic lesions detected by gradient-echo MRI among 46 consecutive patients with symptomatic primary lobar intracerebral hemorrhage diagnosed as probable or possible cerebral amyloid angiopathy. In a second neuropathologic analysis, we performed blinded qualitative and quantitative examinations of amyloid-positive vessel segments in 6 autopsied subjects whose MRI scans de

SUBMITTER: Greenberg SM 

PROVIDER: S-EPMC2758289 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature