Ontology highlight
ABSTRACT:
SUBMITTER: Warotayanont R
PROVIDER: S-EPMC2758297 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Warotayanont Rungnapa R Frenkel Baruch B Snead Malcolm L ML Zhou Yan Y
Biochemical and biophysical research communications 20090716 3
We previously showed that one of the amelogenin splicing isoforms, Leucine-rich amelogenin peptide (LRAP), induced osteogenic differentiation of mouse embryonic stem cells; however, the signaling pathway(s) activated by LRAP remained unknown. Here, we demonstrated that the canonical Wnt/beta-catenin signaling is activated upon LRAP treatment, as evidenced by elevated beta-catenin level and increased Wnt reporter gene activity. Furthermore, a specific Wnt inhibitor sFRP-1 completely blocks the LR ...[more]