Ontology highlight
ABSTRACT:
SUBMITTER: Wegrzyn J
PROVIDER: S-EPMC2758306 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20090108 5915
Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activation of Stat3-responsive genes. We provide evidence that Stat3 is present in the mitochondria of cultured cells and primary tissues, including the liver and heart. In Stat3(-/-) cells, the activities of complexes I and II of the electron transport chain (ETC) were significantly decreased. We identified Stat3 mutants that selectively restored the protein's function as a transcription factor o ...[more]