Polymorphisms in TCEAL7 and risk of epithelial ovarian cancer.

ABSTRACT:

Objective

We have previously shown that TCEAL7 (transcription elongation factor A (SII)-like 7) is epigenetically down-regulated in the majority of epithelial ovarian cancers. We now examine the hypothesis that inherited alterations in TCEAL7 play a role in the etiology of ovarian cancer.

Methods

A two-site case-control study of 930 cases of ovarian cancer and 1037 controls, frequency-matched on residence, age and race, was conducted. Six informative SNPs (tagSNPs and putative-functional SNPs) were genotyped. Logistic regression was used to adjust for potential confounders and determine if inherited variation at this locus was associated with risk of ovarian cancer in general and among cases with invasive disease and serous histology. Gene-level principal component and haplo

SUBMITTER: Peedicayil A 

PROVIDER: S-EPMC2758312 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature