Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm.

ABSTRACT:

Background

We previously established that neutrophils play a critical role in the development of experimental abdominal aortic aneurysm (AAA). The signal that initiates the influx of neutrophils to the aortic wall, however, remains unknown. In this study, we tested the hypothesis that complement participates in the development of AAA by providing the necessary chemotactic signal that recruits neutrophils to the aortic wall.

Methods and results

Using an elastase-induced model of AAA, we showed that pretreatment of C57BL/6 mice with cobra venom factor, which depleted serum of complement activity, protected mice from AAA development. Whereas control mice exhibited a mean aortic diameter of 156+/-2% on day 14 after elastase perfusion, mice treated with cobra venom factor exhibit

SUBMITTER: Pagano MB 

PROVIDER: S-EPMC2758616 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature