Sex hormones and frailty in older men: the osteoporotic fractures in men (MrOS) study.

ABSTRACT:

Context

As men age, the prevalence of frailty increases whereas levels of androgens decline. Little is known about the relation between these factors.

Objective

The aim of this study was to assess cross-sectional and longitudinal associations of estradiol, bioavailable estradiol, testosterone, bioavailable testosterone (bioT), and SHBG with frailty status.

Design and setting

The Osteoporotic Fractures in Men (MrOS) study was conducted at six U.S. clinical centers.

Participants

A total of 1469 community-dwelling men at least 65 yr old with baseline data participated; 1245 men had frailty status reassessed 4.1 yr later.

Main outcome measure

Proportional odds models estimated the likelihood of greater frailty status. Frail men had at least three of the foll

SUBMITTER: Cawthon PM 

PROVIDER: S-EPMC2758722 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature