Association of glucocerebrosidase mutations with dementia with lewy bodies.

ABSTRACT:

Background

Mutations in the glucocerebrosidase (GBA) gene are associated with Lewy body (LB) disorders.

Objective

To determine the relationship of GBA mutations and APOE4 genotype to LB and Alzheimer disease (AD) pathological findings.

Design

Case-control study.

Setting

Academic research.

Participants

The 187 subjects included patients with primary neuropathological diagnoses of LB disorders with or without AD changes (95 cases), randomly selected patients with AD (without significant LB pathological findings; 60 cases), and controls with neither LB nor AD pathological findings (32 cases).

Main outcome measures

GBA mutation status, APOE4 genotype, LB pathological findings (assessed according to the third report of the Dementia With Lewy Body Conso

SUBMITTER: Clark LN 

PROVIDER: S-EPMC2758782 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature