Dissecting the fission yeast regulatory network reveals phase-specific control elements of its cell cycle.

ABSTRACT:

Background

Fission yeast Schizosaccharomyces pombe and budding yeast Saccharomyces cerevisiae are among the original model organisms in the study of the cell-division cycle. Unlike budding yeast, no large-scale regulatory network has been constructed for fission yeast. It has only been partially characterized. As a result, important regulatory cascades in budding yeast have no known or complete counterpart in fission yeast.

Results

By integrating genome-wide data from multiple time course cell cycle microarray experiments we reconstructed a gene regulatory network. Based on the network, we discovered in addition to previously known regulatory hubs in M phase, a new putative regulatory hub in the form of the HMG box transcription factor SPBC19G7.04. Further, we inferred perio

SUBMITTER: Bushel PR 

PROVIDER: S-EPMC2758837 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature